[Home ] [Archive]    
:: Main About Current Issue Archive Search Submit Contact ::
:: Volume 5, Issue 1 (February 2019) ::
RABMS 2019, 5(1): 69-76 Back to browse issues page
Cytotoxicity, Antioxidant and Antibacterial Activities of Crocus Sativus Petal Extract
Ashraf Ahmadi Shadmehri, Farideh Namvar , Hamidreza Miri, Parichehre Yaghmaei, Mahboobeh Nakhaei Moghaddam
Department of Medicine & Applied Biology Research Centre, Mashhad Branch, Islamic Azad University, Mashhad, Iran , nanoscience96@yahoo.com
Abstract:   (575 Views)
Crocus Sativus Petals are a dusted waste that contains bioactive compounds. The aim of this study was to evaluate the cytotoxicity, antioxidant, antibacterial activities of Crocus Sativus petals extract (CSPE). The cytotoxic effects of CSPE on human liver cancer cells (HepG2) were performed using MTT assay. Then, cell morphology was determined by inverted microscope. The antioxidant activity of CSPE was evaluated using DPPH and ABTS assays. Antibacterial activity of CSPE was tested against gram-negative bacteria Escherichia coli (E. coli) and gram positive bacteria staphylococcus aureus (S. aureus) using macrodilution method. CSPE inhibited the proliferation of the HepG2 cell line in a time and dose-dependent manner, which was consistent with morphological changes. Extract showed the enhanced antioxidant properties and also were found effective against the bacterial strains. Due to the anti-proliferative, antioxidant, antibacterial effects of CSPE, it can be used in pharmaceutical industry, including the production of anticancer, antioxidants and antibacterial drugs.
Keywords: Crocus Sativus petal extract, HepG2, antioxidant activity, antibacterial activity, pharmaceutical industry
Full-Text [PDF 830 kb]   (319 Downloads)    
Type of Study: orginal article | Subject: General
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ahmadi Shadmehri A, Namvar F, Miri H, Yaghmaei P, Nakhaei Moghaddam M. Cytotoxicity, Antioxidant and Antibacterial Activities of Crocus Sativus Petal Extract. RABMS. 2019; 5 (1) :69-76
URL: http://ijrabms.umsu.ac.ir/article-1-82-en.html

Volume 5, Issue 1 (February 2019) Back to browse issues page
Journal of Research in Applied and Basic Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 4212