Volume 5, Issue 1 (February 2019)
Journal of Research in Applied and Basic Medical Sciences 2019, 5(1): 69-76 |
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Ahmadi Shadmehri A, Namvar F, Miri H, Yaghmaei P, Nakhaei Moghaddam M. Cytotoxicity, Antioxidant and Antibacterial Activities of Crocus Sativus Petal Extract. Journal of Research in Applied and Basic Medical Sciences 2019; 5 (1) :69-76
URL: http://ijrabms.umsu.ac.ir/article-1-82-en.html
URL: http://ijrabms.umsu.ac.ir/article-1-82-en.html
Ashraf Ahmadi Shadmehri 
, Farideh Namvar * 
, Hamidreza Miri , Parichehre Yaghmaei , Mahboobeh Nakhaei Moghaddam
, Farideh Namvar * , Hamidreza Miri , Parichehre Yaghmaei , Mahboobeh Nakhaei Moghaddam
Department of Medicine & Applied Biology Research Centre, Mashhad Branch, Islamic Azad University, Mashhad, Iran , nanoscience96@yahoo.com
Abstract: (3199 Views)
Crocus Sativus Petals are a dusted waste that contains bioactive compounds. The aim of this study was to evaluate the cytotoxicity, antioxidant, antibacterial activities of Crocus Sativus petals extract (CSPE). The cytotoxic effects of CSPE on human liver cancer cells (HepG2) were performed using MTT assay. Then, cell morphology was determined by inverted microscope. The antioxidant activity of CSPE was evaluated using DPPH and ABTS assays. Antibacterial activity of CSPE was tested against gram-negative bacteria Escherichia coli (E. coli) and gram positive bacteria staphylococcus aureus (S. aureus) using macrodilution method. CSPE inhibited the proliferation of the HepG2 cell line in a time and dose-dependent manner, which was consistent with morphological changes. Extract showed the enhanced antioxidant properties and also were found effective against the bacterial strains. Due to the anti-proliferative, antioxidant, antibacterial effects of CSPE, it can be used in pharmaceutical industry, including the production of anticancer, antioxidants and antibacterial drugs.
Keywords: Crocus Sativus petal extract, HepG2, antioxidant activity, antibacterial activity, pharmaceutical industry
Type of Study: orginal article |
Subject:
General
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