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Mahmoodi A, Qujeq D, Danesh doust D, Karimi M. Determination of Serum Survivin for Prognostic Role in Esophageal Cancer. Journal of Research in Applied and Basic Medical Sciences 2020; 6 (1) :9-13
URL: http://ijrabms.umsu.ac.ir/article-1-93-en.html
Babol University of Medical Sciences, Babol, Iran , dqujeq@gmail.com
Abstract:   (3447 Views)
Background & Aims: In the recent years, the considerable interest in survivin has significantly increased, because of its possible detection role in esophageal cancer.
Materials and Methods: Twenty eight patients diagnosed with esophageal cancer and thirty three healthy controls were assessed for the purpose of the study. From March 2015 until September 2017, the subjects who had esophageal cancer were enrolled in the study. Blood samples were from subjects enrolled in a prospective cohort undergoing annual esophageal cancer testing. The concentrations of serum survivin were determined using Elisa method.
Results: Serum levels of survivin in the esophageal patient group increased compared to the healthy controls [164.06±55.03 (mean±SD) vs. 119.37±48.25, ng/L, P<0.04].Elevated serum survivin had positive correlation with clinical parameters.
Conclusion: The positive association between elevated serum survivin and esophageal cancer status could be due to the fact that this protein involves in the development of esophageal cancer. Determination of serum survivin could differentiate normal and esophageal cancer subjects and lead to lower numbers of excessive esophageal biopsies.
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Type of Study: orginal article | Subject: General

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