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Mohammadpour M, Farjah G H. Protective Effect of Crocin on Ovarian Ischemia-Reperfusion Injury in Rats. Journal of Research in Applied and Basic Medical Sciences 2020; 6 (4) :199-206
URL: http://ijrabms.umsu.ac.ir/article-1-126-en.html
Neurophysiology Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran , Farjah.GH@umsu.ac.ir
Abstract:   (2484 Views)
Background & Aims: Ischemia-reperfusion (I-R) injury of the ovary may lead to ovarian injury. In this study, we investigated the protective effect of the crocin on ovarian I-R injury.
Materials & Methods: Thirty-six male Sprague-Dawley rats were divided into 6 groups: sham surgery, ischemia, I-R, I-R+normal saline (NS), I-R+low dose crocin (20 mg/kg crocin), and I-R+ high dose crocin (80 mg/kg crocin). Neurological function, biochemical and histological evaluation was done 72 hours after ischemia.
Results: The plasma levels of malondialdehyde (MDA) and Total Antioxidative Capacity (TAC) in the ischemia, I-R, and I-R+ NS groups increased and decreased significantly compared to the crocin groups, respectively (p<0.01, p<0.05, respectively). Catalase activity in the high dose crocin group was higher than the ischemia, I-R, and I-R+ NS groups (p<0.01). The mean scores of edema, congestion, hemorrhage, and follicular degeneration were significantly lower than in the crocin groups than in the ischemia, I-R, and I-R+NS groups (p<0.05).
Conclusion: Findings suggest that crocin may protect ovary from ischemia-reperfusion injury.
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Type of Study: orginal article | Subject: Special

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