Tumors of salivary glands: an institutional study

Kanala, Mahaboob Chan; P, Chaturya Kalanidhi; Vaddadi, Vishali; Muchalapuri, Sravani; Rasheed, Fatima; Balagouni, Shruthi; Chari, Sumanjali

doi:10.61186/rabms.11.2.176

Volume 11, Issue 2 (4-2025) Journal of Research in Applied and Basic Medical Sciences 2025, 11(2): 176-185 | Back to browse issues page

‎ 10.61186/rabms.11.2.176

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Kanala M C, P C K, Vaddadi V, Muchalapuri S, Rasheed F, Balagouni S et al . Tumors of salivary glands: an institutional study. Journal of Research in Applied and Basic Medical Sciences 2025; 11 (2) :176-185
URL: http://ijrabms.umsu.ac.ir/article-1-379-en.html

Tumors of salivary glands: an institutional study

Mahaboob Chan Kanala

, Chaturya Kalanidhi P

, Vishali Vaddadi

, Sravani Muchalapuri ^*

, Fatima Rasheed

, Shruthi Balagouni

, Sumanjali Chari

Assistant Professor, Department of pathology, SVS Medical College and Hospital, Yenugonda, Mahabubnagar, Telengana-509001 , research.nmch@rediffmail.com

Abstract: (207 Views)

Background & Aims: This research investigates the clinicopathological features of salivary gland tumors by employing a range of markers, such as pancytokeratin (CKAE1/CKAE3), α-smooth muscle actin (SMA), carcinoembryonic antigen (CEA), and p63.
Materials & Methods: The research investigated formalin-fixed paraffin-embedded (FFPE) tissue slides stained with hematoxylin and eosin (H & E) from a total of 32 cases of salivary gland tumors.
Results: Lesions were detected in individuals ranging from 11 to 79 years of age, with a mean age of 45.5 years. Among the cases analyzed, 19 (59.4%) were categorized as benign neoplasms, which included 12 instances of pleomorphic adenoma (PA), 4 instances of basal cell adenoma (BCA), 2 instances of myoepithelioma, and 1 instance of Warthin's tumor. Conversely, 13 cases (40.6%) were identified as malignant neoplasms, consisting of 7 cases of mucoepidermoid carcinoma, 4 cases of adenoid cystic carcinoma (ACC), 1 case of carcinoma ex pleomorphic adenoma (Ca ex PA), and 1 case of squamous cell carcinoma (SCC). Immunohistochemical analysis demonstrated p63 positivity in PA, BCA, ACC, and SCC. Furthermore, positivity for cytokeratin was found in BCA, ACC, PA, and SCC. SMA positivity was observed in both BCA and ACC.
Conclusion: The predominant benign and malignant tumors of the salivary glands are PA and mucoepidermoid carcinoma (MEC). Immunohistochemical staining of both epithelial and myoepithelial cells serves not only to validate the diagnosis but also assists in formulating the most appropriate treatment strategy.

Keywords: α-smooth muscle actin, Carcinoembryonic antigen, Salivary gland tumors, Squamous cell carcinoma

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Type of Study: orginal article | Subject: General

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