Tropisetron ameliorates oxidative stress in type-1 diabetic experimental rats

gholizadeh-Ghaleh Aziz, Shiva; Naderi, Roya; Khalaji, Naser; Mahmodian, Nima

Volume 4, Issue 2 (October 2018) Journal of Research in Applied and Basic Medical Sciences 2018, 4(2): 102-107 | Back to browse issues page

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gholizadeh-Ghaleh Aziz S, Naderi R, Khalaji N, Mahmodian N. Tropisetron ameliorates oxidative stress in type-1 diabetic experimental rats. Journal of Research in Applied and Basic Medical Sciences 2018; 4 (2) :102-107
URL: http://ijrabms.umsu.ac.ir/article-1-71-en.html

Tropisetron ameliorates oxidative stress in type-1 diabetic experimental rats

Shiva Gholizadeh-Ghaleh Aziz

, Roya Naderi ^*

, Naser Khalaji

, Nima Mahmodian

Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran , r_naderi_s@yahoo.com

Abstract: (3035 Views)

In this study, we evaluated the effect of tropisetron on the oxidative biomarkers in the plasma of type 1 diabetes mellitus (DM). Twenty-one male Wistar rats were randomly divided into three experimental groups (n =7): control, diabetic and diabetic + tropisetron. Diabetes type 1 was induced by streptozotocin (STZ) (50 mg/kg; i.p). Tropisetron (3 mg/kg; i.p) as a 5-HT3 antagonist was given once daily for 2 weeks. At the end of experiment animals were euthanized and blood samples were collected for further analysis including superoxide dismutase (SOD), glutathione peroxidase (GPx) activities and malondialdehyde (MDA), total antioxidant capacity (TAC) levels. We found that tropisetron attenuated MDA levels and increased SOD, GPx and TAC contents in the plasma of diabetic rats. Our findings indicate that tropisetron improved oxidative stress in the plasma of STZ induced-diabetic rats.

Keywords: Diabetes, Tropisetron, Oxidative stress, Rat

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Type of Study: orginal article | Subject: General