Phyloevolutionary analysis of delta variant of SARS-CoV 2 in Nigeria

Irokosu, Emmanuel; Oladoja, Farouk

doi:10.52547/rabms.8.1.50

Volume 8, Issue 1 (3-2022) Journal of Research in Applied and Basic Medical Sciences 2022, 8(1): 50-55 | Back to browse issues page

‎ 10.52547/rabms.8.1.50

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Irokosu E, Oladoja F. Phyloevolutionary analysis of delta variant of SARS-CoV 2 in Nigeria. Journal of Research in Applied and Basic Medical Sciences 2022; 8 (1) :50-55
URL: http://ijrabms.umsu.ac.ir/article-1-182-en.html

Phyloevolutionary analysis of delta variant of SARS-CoV 2 in Nigeria

Emmanuel Irokosu

, Farouk Oladoja ^*

Olabisi Onabanjo University , adedeji.oladoja@oouagoiwoye.edu.ng

Abstract: (1571 Views)

Background & Aims: The evolution of SARS-CoV-2 from its inception created a need for phyloepidemiological approaches to provide unanswered questions regarding the viral emergence and evolvement of various mutated strains. Unfortunately, there is an absolute dearth of information on the evolution of the delta variant strain in Nigeria. This study investigated the phyloepidemiology of the delta variant of SARS-CoV-2 in Nigeria.
Materials & Methods: A total of 33 complete genomic sequences of the SARS-CoV-2 delta variant (B.1.617.2) from Nigeria, India, United Arab Emirates (UAE), United States of America (USA), Canada, United Kingdom (UK), China, and the reference sequence were retrieved from the GISAID EpiFlu™ on the 11^th of August 2021. The sequences were selected based on the most visited tourist destinations of Nigerians (USA, UK, China, UAE, India, and Canada). The evolutionary history was inferred using the maximum likelihood method based on the general time-reversible model. Finally, a phylogenetic tree was constructed to determine the common ancestor of each sequence.
Results: The phylogenetic analysis revealed that the delta strain in Nigeria clustered in a monophyletic clade with other Nigeria strains with its root from the reference Wuhan sublineage. Nucleotide alignment also showed a 99% similarity indicating a common origin of evolution.
Conclusion: Our findings revealed that the current outbreak of the delta variant of SARS-CoV-2 infection in Nigeria stemmed from a genetic mutation that shared a consensus similarity with the reference SARS-CoV-2 human genome from Wuhan and was not imported from other countries as widely reported.

Keywords: Delta Variant, Genome Sequence, Phyloevolution, SARS-CoV-2

Full-Text [PDF 528 kb] (597 Downloads)

Type of Study: orginal article | Subject: General

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