Effect of Antihypertensive Drugs on Placental Villi of Preeclamptic Patients: A Histopathological Study

Ansari, Hamid; Ansari, Mohammad Faizan; Gupta, Smrity; Das, Medha

doi:10.52547/rabms.8.2.64

Volume 8, Issue 2 (5-2022) Journal of Research in Applied and Basic Medical Sciences 2022, 8(2): 64-68 | Back to browse issues page

‎ 10.52547/rabms.8.2.64

Mendeley

Zotero

RefWorks

Ansari H, Ansari M F, Gupta S, Das M. Effect of Antihypertensive Drugs on Placental Villi of Preeclamptic Patients: A Histopathological Study. Journal of Research in Applied and Basic Medical Sciences 2022; 8 (2) :64-68
URL: http://ijrabms.umsu.ac.ir/article-1-188-en.html

Effect of Antihypertensive Drugs on Placental Villi of Preeclamptic Patients: A Histopathological Study

Hamid Ansari ^*

, Mohammad Faizan Ansari

, Smrity Gupta

, Medha Das

Associate Professor, Rama Medical College & Research Centre, Kanpur,UP,India , hamidansari78@gmail.com

Abstract: (2096 Views)

Background & Aims: The placenta has been described as the most accurate record of the infant’s prenatal experience. The present study was a quantitative study and it was carried out to see the effect of pre-eclampsia on histopathology of placenta and the comparative changes in placenta of preeclamptic patients taking antihypertensives.
Materials & Methods: A total of 60 patients were selected from the Obstetrics and Gynecology Department of Jawahar Lal Nehru Medical College & Hospital, AMU, Aligarh, UP, India and were grouped into control, untreated, and treated groups. Placenta of each group was fixed in 10% formalin solution and processed for section cutting. 5-micron thick sections were prepared and stained with Hematoxylin-eosin and Wiegerts & Van gieson stain and observed under the light of the microscope. A total of 200villi/hpf was counted and percentages for each parameter were expressed.
Result: It has been shown that there was a significant reduction (<0.05) in the percentage of placental villi showing syncytial knot, cytotrophoblast proliferation, Basement membrane thickening, fibrinoid necrosis, and stromal fibrosis.
Conclusion: It has been concluded that antihypertensive drugs were not only effective in controlling the symptoms of pre-eclampsia but also effective in minimizing the placental histopathology and helpful in continuation of pregnancy under low utero-placental flow without completely normalizing the placental changes.

Keywords: Pre-eclampsia, Methyldopa, Chorionic villi, Basement membrane

Full-Text [PDF 288 kb] (777 Downloads)

Type of Study: orginal article | Subject: General

References

1. Benirshke K. Examination of the placenta. Obstet Gynaecol 1961; 18: 309. [Google Scholar]

2. Brosen I, Dixon HG, Robertson WB. Fetal growth retardation and the arteries of the placental bed. Br J Obst Gynaec 1977; 84: 656-63. [DOI:10.1111/j.1471-0528.1977.tb12676.x] [PMID]

3. Fox H. The morphological basis of placental insufficiency. J Obstet Gynaec India 1975; 25 (4): 441-50. [Google Scholar]

4. Majumdar S, Dasgupta H, Bhattacharya K, Bhattacharya A. A study of placenta in normal and hypertensive pregnancies. J Anat Soc India 2005; 54(2); 34-8. [URL]

5. Falkay G, Melis K, Kovacs L. Correlation between beta and alpha adrenergic receptor concentrations in human placenta. J Recept Res 1994; 14(3-4): 187-95. [DOI:10.3109/10799899409066030] [PMID]

6. Anderson HR, Mckey DG. Electron microscopic study of the trophoblast in normal and toxaemic placentas. Am J Obst Gynaecol 1966; 95: 1134. [DOI:10.1016/S0002-9378(66)80016-9] [PMID]

7. Jones CJP, Fox H. An ultrastructural and ultrahistochemical study of the human placenta in maternal preeclampsia. Placenta 1980; 1: 61- 76 [DOI:10.1016/S0143-4004(80)80016-6] [PMID]

8. Mirchandani JS, Mallik GB, Chitra S. Villous fibrinoid necrosis and basement membrane thickening in toxaemia of pregnancy and its intrauterine growth retardation. J Obst. Gynaecol India 1979; 29: 1131.

9. Masodkar AR, Kalamkar LR, Patki PS. Histopathology of placenta and its correlation with fetal outcome. J Obst Gynaecol India 1985; 35:294. [URL]

10. Sodhi S, Mohan H, Rathee S. and Mohan. Placental pathology in pre-eclempsia syndrome. Indian J Pathol Microbiol 1990; 33: 1; 11-6. [Google Scholar]

11. Majumdar S, Dasgupta H, Bhattacharya K, Bhattacharya A. A study of placenta in normal and hypertensive pregnancies. J Anat Soc India 2005; 54(2); 34-8.

12. Fox H. The significance of villous syncytial knots in the human placenta. J Obst Gynaecol Br Common W 1965; 74: 28. [DOI:10.1111/j.1471-0528.1967.tb03928.x] [PMID]

13. Fox H. The villous cytotrophoblast as an index of placental ischaemia. J Obstet Gynaecol J Br Common W 1964; 71: 885. [DOI:10.1111/j.1471-0528.1964.tb04375.x] [PMID]

14. Genset DR. Estimating the time of death of stillbirth fetuses-II. A study of 71 stillborns. Br J Obstet Gynaecol 1992; 80: 585-92. [PMID]

15. Krielessi V, Papantoniou N, Papageorgiou I, Chatzipapas I, Manios E, Zakopoulos N, et al. Placental Pathology and Blood Pressure's Level in Women with Hypertensive Disorders in Pregnancy. Obstet Gynecol Int 2012; 2012:684083. [DOI:10.1155/2012/684083] [PMID] [PMCID]

16. Ezeigwe CO, Okafor CI, Eleje GU, Udigwe GO, Anyiam DC. Placental peripartum pathologies in women with preeclampsia and eclampsia. Obstet Gynecol Int 2018; 2018: 9462938.Khalil A, Muttukrishna S, Harrington K, Jauniaux E. Effect of Antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. PLOS ONE 2008; 3(7): e2766. [DOI:10.1371/journal.pone.0002766] [PMID] [PMCID]