Exploring the link between serum vitamin d and anti-müllerian hormone in polycystic ovary syndrome among reproductive-age women

Arumalla, Veerendra Kumar; Kotam, Rajashaker Reddy

doi:10.61186/rabms.10.2.103

Volume 10, Issue 2 (4-2024) Journal of Research in Applied and Basic Medical Sciences 2024, 10(2): 103-109 | Back to browse issues page

‎ 10.61186/rabms.10.2.103

Mendeley

Zotero

RefWorks

Arumalla V K, Kotam R R. Exploring the link between serum vitamin d and anti-müllerian hormone in polycystic ovary syndrome among reproductive-age women. Journal of Research in Applied and Basic Medical Sciences 2024; 10 (2) :103-109
URL: http://ijrabms.umsu.ac.ir/article-1-315-en.html

Exploring the link between serum vitamin d and anti-müllerian hormone in polycystic ovary syndrome among reproductive-age women

Veerendra Kumar Arumalla ^*

, Rajashaker Reddy Kotam

Associate Professor, Department of Biochemistry, ESIC Medical College & PGIMSR & Model Hospital, Rajajinagar, Bangalore, Karnataka, India-560010 , drveerendraarumalla@gmail.com

Abstract: (996 Views)

Background & Aims: Several studies were conducted earlier to find the association between serum Vitamin- D and Anti-Müllerian hormone (AMH) levels among women with Polycystic Ovary Syndrome (PCOS). The results from the existing studies were inconsistent. The objective of the present study was to find out the association between serum Vitamin D and AMH levels among women with PCOS.
Materials & Methods: A cross-sectional study was conducted in a Tertiary Care Teaching hospital in South India, 120 PCOS and 60 controls were included in the study. Age, Body Mass Index (BMI), Follicular Stimulating Hormone (FSH), Luteinizing hormone (LH), Estradiol (E2), Antral Follicular Count (AFC), Anti-Müllerian hormone (AMH), and 25-hydroxyvitamin D (25(OH)D) were analyzed among PCOS and control groups and comparisons were made.
Results: There was no significant difference (P =0.925) in the Vitamin D levels among PCOS and control groups. There was a positive correlation (r = 0.392; p = 0.002) between Vitamin D levels and AMH levels among PCOS group.
Conclusion: The present study revealed that there was no significant difference between Vitamin D levels among PCOS and control groups. There was weak positive correlation between Vitamin D levels and AMH levels among PCOS group. Multilinear regression analysis with AMH as dependent variable and other parameters as dependent variables in PCOS group revealed that AMH levels were independently correlated with age but not with Vitamin D.

Keywords: Anti Müllerian Hormone, Polycystic Ovary Syndrome, Vitamin D Deficiency

Full-Text [PDF 236 kb] (585 Downloads) | | Full-Text (HTML) (415 Views)

Type of Study: orginal article | Subject: General

References

1. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7): 1911-30. http: //dx.doi.org/10.1210/jc.2011-0385 [DOI:10.1210/jc.2011-0385] [PMID]

2. Fauser BCJM, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, et al. Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 2012;97(1): 28-38.e25. http: //dx.doi.org/10.1016/j.fertnstert.2011.09.024. [DOI:10.1016/j.fertnstert.2011.09.024] [PMID]

3. Bhattacharya SM, Jha A. Association of vitamin D3 deficiency with clinical and biochemical parameters in Indian women with polycystic ovary syndrome. Int J Gynaecol Obstet 2013;123(1): 74-5. http: //dx.doi.org/10.1016/j.ijgo.2013.04.021 [DOI:10.1016/j.ijgo.2013.04.021] [PMID]

4. Pellatt L, Hanna L, Brincat M, Galea R, Brain H, Whitehead S, et al. Granulosa cell production of anti-Müllerian hormone is increased in polycystic ovaries. J Clin Endocrinol Metab 2007;92(1): 240-5. http: //dx.doi.org/10.1210/jc.2006-1582 [DOI:10.1210/jc.2006-1582] [PMID]

5. Vendola KA, Zhou J, Adesanya OO, Weil SJ, Bondy CA. Androgens stimulate early stages of follicular growth in the primate ovary. J Clin Invest 1998;101(12): 2622-9. http: //dx.doi.org/10.1172/JCI2081 [DOI:10.1172/JCI2081] [PMID] []

6. Merhi Z, Doswell A, Krebs K, Cipolla M. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab 2014;99(6): E1137-45. http: //dx.doi.org/10.1210/jc.2013-4161 [DOI:10.1210/jc.2013-4161] [PMID] []

7. Kim S, Kim JJ, Kim MJ, Han KH, Lee JR, Suh CS, et al. Relationship between serum anti-Mullerian hormone with vitamin D and metabolic syndrome risk factors in late reproductive-age women. Gynecol Endocrinol 2018;34(4): 327-31. http: //dx.doi.org/10.1080/09513590.2017.1397113 [DOI:10.1080/09513590.2017.1397113] [PMID]

8. Jukic AM, Wilcox AJ, Weinberg CR, Baird DD, Steiner AZ. 25-Hydroxyvitamin D (25 (OH) D) and biomarkers of ovarian reserve. Vol. 25. New York, NY: Menopause; 2018. http: //doi: 10.1097/gme.0000000000001075 [DOI:10.1097/GME.0000000000001075] [PMID] []

9. Aramesh S, Alifarja T, Jannesar R, Ghaffari P, Vanda R, Bazarganipour F. Does vitamin D supplementation improve ovarian reserve in women with diminished ovarian reserve and vitamin D deficiency: a before-and-after intervention study. BMC Endocr Disord 2021;21(1): 126. http: //dx.doi.org/10.1186/s12902-021-00786-7 [DOI:10.1186/s12902-021-00786-7] [PMID] []

10. Wong HYQ, Li HWR, Lam KSL, Tam S, Shek CC, Lee CYV, et al. Independent association of serum vitamin D with anti-Mullerian hormone levels in women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 2018;89(5): 634-41. http: //dx.doi.org/10.1111/cen.13816 [DOI:10.1111/cen.13816] [PMID]

11. Bednarska-Czerwińska A, Olszak-Wąsik K, Olejek A, Czerwiński M, Tukiendorf AA. Vitamin D and anti-Müllerian hormone levels in infertility treatment: The change-point problem. Nutrients 2019;11(5): 1053. http: //dx.doi.org/10.3390/nu11051053 [DOI:10.3390/nu11051053] [PMID] []

12. Liu X, Zhang W, Xu Y, Chu Y, Wang X, Li Q, et al. Effect of vitamin D status on normal fertilization rate following in vitro fertilization. Reprod Biol Endocrinol 2019;17(1): 59. http: //dx.doi.org/10.1186/s12958-019-0500-0 [DOI:10.1186/s12958-019-0500-0] [PMID] []

13. Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;19(1): 41-7. http: //dx.doi.org/10.1093/humrep/deh098 [DOI:10.1093/humrep/deh098] [PMID]

14. Merhi ZO, Seifer DB, Weedon J, Adeyemi O, Holman S, Anastos K, et al. Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women: Women's Interagency HIV Study. Fertil Steril 2012;98(1): 228-34. http: //dx.doi.org/10.1016/j.fertnstert.2012.03.029 [DOI:10.1016/j.fertnstert.2012.03.029] [PMID] []

15. Chang EM, Kim YS, Won HJ, Yoon TK, Lee WS. Association between sex steroids, ovarian reserve, and vitamin D levels in healthy nonobese women. J Clin Endocrinol Metab 2014;99(7): 2526-32. http: //dx.doi.org/10.1210/jc.2013-3873 [DOI:10.1210/jc.2013-3873] [PMID]

16. Dennis N, Houghton L, Pankhurst M, Harper M, McLennan I. Acute supplementation with high dose vitamin D3 increases serum anti-müllerian hormone in young women. Nutrients 2017;9(7): 719. http: //dx.doi.org/10.3390/nu9070719 [DOI:10.3390/nu9070719] [PMID] []

17. Dennis NA, Houghton LA, Jones GT, van Rij AM, Morgan K, McLennan IS. The level of serum anti-Müllerian hormone correlates with vitamin D status in men and women but not in boys. J Clin Endocrinol Metab 2012;97(7): 2450-5. http: //dx.doi.org/10.1210/jc.2012-1213 [DOI:10.1210/jc.2012-1213] [PMID]

18. Naderi Z, Kashanian M, Chenari L, Sheikhansari N. Evaluating the effects of administration of 25-hydroxyvitamin D supplement on serum anti-mullerian hormone (AMH) levels in infertile women. Gynecol Endocrinol 2018;34(5): 409-12. http: //dx.doi.org/10.1080/09513590.2017.1410785 [DOI:10.1080/09513590.2017.1410785] [PMID]

19. Cappy H, Giacobini P, Pigny P, Bruyneel A, Leroy-Billiard M, Dewailly D. Low vitamin D3 and high anti-Müllerian hormone serum levels in the polycystic ovary syndrome (PCOS): Is there a link? Ann Endocrinol (Paris). Ann Endocrinol (Paris) 2016;77(5): 593-9. http: //dx.doi.org/10.1016/j.ando.2016.02.001 [DOI:10.1016/j.ando.2016.02.001] [PMID]

20. Irani M, Minkoff H, Seifer DB, Merhi Z. Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J Clin Endocrinol Metab 2014;99(5): E886-90. http: //dx.doi.org/10.1210/jc.2013-4374 [DOI:10.1210/jc.2013-4374] [PMID]

21. Dastorani M, Aghadavod E, Mirhosseini N, Foroozanfard F, Zadeh Modarres S, Amiri Siavashani M, et al. The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization. Reprod Biol Endocrinol 2018;16(1): 94. http: //dx.doi.org/10.1186/s12958-018-0413-3 [DOI:10.1186/s12958-018-0413-3] [PMID] []

22. Garg D, Tal R. The role of AMH in the pathophysiology of polycystic ovarian syndrome. Reprod Biomed Online 2016;33(1): 15-28. http: //dx.doi.org/10.1016/j.rbmo.2016.04.007 [DOI:10.1016/j.rbmo.2016.04.007] [PMID]

23. Szafarowska M, Dziech E, Kaleta B, Kniotek M, Rogowski A, Segiet - Święcicka A, et al. Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome. J Assist Reprod Genet 2019;36(6): 1281-9. http: //dx.doi.org/10.1007/s10815-019-01472-3 [DOI:10.1007/s10815-019-01472-3] [PMID] []