Prevalence and antimicrobial susceptibility profile of clinical isolates of Citrobacter spp. at a tertiary care hospital in Madhya Pradesh

Mehta, Abhishek; Mungi, Vismit; Jain, Sagar

doi:10.61186/rabms.10.3.285

Volume 10, Issue 3 (7-2024) Journal of Research in Applied and Basic Medical Sciences 2024, 10(3): 285-290 | Back to browse issues page

‎ 10.61186/rabms.10.3.285

Ethics code: 1346/IECBMHR/GMC/2024

Mendeley

Zotero

RefWorks

Mehta A, Mungi V, Jain S. Prevalence and antimicrobial susceptibility profile of clinical isolates of Citrobacter spp. at a tertiary care hospital in Madhya Pradesh. Journal of Research in Applied and Basic Medical Sciences 2024; 10 (3) :285-290
URL: http://ijrabms.umsu.ac.ir/article-1-343-en.html

Prevalence and antimicrobial susceptibility profile of clinical isolates of Citrobacter spp. at a tertiary care hospital in Madhya Pradesh

Abhishek Mehta ^*

, Vismit Mungi

, Sagar Jain

Associate Professor, Department of Microbiology, Government Medical College, Datia, Madhya Pradesh, India , abhishekmehta623@gmail.com

Abstract: (361 Views)

Background & Aims: Citrobacter, a member of the Enterobacteriaceae family known to be a normal intestinal flora and an opportunistic pathogen is now increasingly found to cause a variety of infections in community as well as hospital settings. It was initially considered a low virulence pathogen but is now found to cause multi-drug resistant infections with high morbidity and mortality. To determine the prevalence of infections caused by Citrobacter spp. and theirAntibiotic sensitivity pattern.
Material & Methods: A Laboratory records-based Cross-sectional study was undertaken retrospectively wherein the laboratory data about 50 Citrobacter spp. isolates obtained from 1628 clinical samples processed over 18 months were retrieved and analyzed at Department of Microbiology, Government Medical College-Datia, Central India in January 2024.
Result: Out of the 1628 samples processed, significant bacterial growth was reported in 770 samples out of which 50 were found to be positive for Citrobacter spp. (6.4%). Isolation rate for Citrobacter spp. was reported to be 3.1 %.The majority of isolates were obtained from Urine (49%) and pus (45%) samples with C. koseri being dominant in urine and C. freundii in pus. Amongst these isolates, 52% were C.koseri, 46% were C.freundii and 4% were other species.
Conclusion: The findings of the study conducted in January 2024 at Datia (Madhya Pradesh) indicate a change in susceptibility trends of emerging pathogens like Citrobacter spp. exhibiting resistance to routinely prescribed antimicrobials, stressing the need for an appropriate action plan involving periodic surveillance, antimicrobial stewardship, and strict implementation of infection control practices.

Keywords: Citrobacter spp., Clinical isolates, Antimicrobial susceptibility pattern, Samples

Full-Text [PDF 329 kb] (182 Downloads)

Type of Study: orginal article | Subject: Microbiology

References

1. Winn WC, Koneman EW. Koneman's Color Atlas and Textbook of Diagnostic Microbiology. Lippincott Williams & Wilkins; 2006. [GOOGLE BOOKS]

2. Poonam AR, Bilolikar AK, Reddy SG. Prevalence and antimicrobial susceptibility pattern of Citrobacter species in various clinical samples in a tertiary care hospital. J Med Sci Res 2019;7(4):103-108. DOI: http://dx.doi.org/10.17727/JMSR.2019/7-18 [DOI:10.17727/JMSR.2019/7-18]

3. Kalpana S, Gajendra Varma. Antibiotic-Resistant Pattern of Citrobacter Species Isolated from Various Clinical Samples at VIMS Hospital, Ballari. J Microbiol Rel at Res 2019;5(2):71-74. [URL]

4. CLSI. Performance Standards for Antimicrobial Susceptibility Testing, M100 32nd Edition. Clinical and Laboratory Standards Institute, Wayne, PA; 2022. [URL]

5. Sadhna S, Hawaldar R. Prevalence and drug resistance pattern of Citrobacter spp. -A retrospective study. Indian J Microbiol Res 2019;6(2):142-5. [DOI:10.18231/j.ijmr.2019.030]

6. Nayar R, Shukla I, Sultan A. Epidemiology, Prevalence and Identification of Citrobacter Species in Clinical Specimens in a Tertiary Care Hospital in India. International Journal of Scientific and Research Publications 2014;4(4):1-6. [GOOGLE SCHOLAR]

7. Dhanya A, Bhat S. Clinicomicrobiological study of infections due to Citrobacter species. Journal of Evolution of Medical and Dental Sciences 2015;4:7327-31. DOI: 10.14260/jemds/2015/1063. [DOI:10.14260/jemds/2015/1063]

8. Dhason MT, Kamalasekaran LT, Chelliah A, Parthasarathy A, Suganthi, Manikeshi, et al. Prevalence of Citrobacter species in various clinical samples and their antibiotic susceptibility pattern study from a tertiary care center in South India. Int J Acad Med Pharm 2023;5(6):520-524. [GOOGLE SCHOLAR]

9. Ranjan KP, Ranjan Neelima. Citrobacter: An emerging healthcare-associated urinary pathogen. Urology Annals 2013;5(4):313-314. [DOI:10.4103/0974-7796.120297]

10. Metri, Basavaraj C, Jyothi P, Peerapur, Basavaraj V. Antibiotic resistance in Citrobacter spp. isolated from urinary tract infection. Urology Annals 2013;5(4):312-313. DOI: 10.4103/0974-7796.120295 [DOI:10.4103/0974-7796.120295] [PMID] []

11. Priyadarshini, Rani KL, Ramaswamy R. Isolation and antibiotic sensitivity pattern of Citrobacter species with ESBL and AmpC detection at Tertiary Care Hospital, Bangalore. J. Evolution Med. Dent Sci. 2016;5(30):1553-1556. DOI: 10.14260/jemds/2016/365 [DOI:10.14260/jemds/2016/365]

12. Sami H, Sultan A, Rizvi M, Fatima K, Ahmad S, Shukla I, Khan HM. Citrobacter as a uropathogen, its prevalence and antibiotics susceptibility pattern. CHRISMED Journal of Health and Research 2017;4(1):23-26. DOI: 10.4103/2348-3334.196037 [DOI:10.4103/2348-3334.196037]

13. Kumar S, Kumar S, Mittal S, Kumari P. Citrobacter spp. Isolated from Pus Samples in a Tertiary Care Hospital and its Antibiogram in Sonepat, Haryana, India. Int J Sci Stud 2020;7(12):14-17. [GOOGLE SCHOLAR]

14. Praharaj AK, Khajuria A, Kumar M, Grover N. Phenotypic detection and molecular characterization of beta-lactamase genes among Citrobacter species in a tertiary care hospital. Avicenna J Med 2016;6(1):17-27. DOI: 10.4103/2231-0770.173578 [DOI:10.4103/2231-0770.173578] [PMID] []