Antimicrobial profile of urinary tract infections at a tertiary care teaching hospital of Central India

Mehta, Abhishek; Gurjar, Dharmendra Singh; Rajak, Vijay Singh

doi:10.61186/rabms.10.4.318

Volume 10, Issue 4 (11-2024) Journal of Research in Applied and Basic Medical Sciences 2024, 10(4): 318-323 | Back to browse issues page

‎ 10.61186/rabms.10.4.318

Ethics code: 1223/IECBMHR/GMC/2023

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Mehta A, Gurjar D S, Rajak V S. Antimicrobial profile of urinary tract infections at a tertiary care teaching hospital of Central India. Journal of Research in Applied and Basic Medical Sciences 2024; 10 (4) :318-323
URL: http://ijrabms.umsu.ac.ir/article-1-361-en.html

Antimicrobial profile of urinary tract infections at a tertiary care teaching hospital of Central India

Abhishek Mehta ^*

, Dharmendra Singh Gurjar

, Vijay Singh Rajak

Associate Professor, Department of Microbiology, Govt. Medical College, Datia (M.P.), India , abhishekmehta623@gmail.com

Abstract: (758 Views)

Background & Aims: Urinary tract infections (UTI) are a leading cause of bacterial infections in humans.The widespread use of antibiotics has resulted in the emergence of antibiotic-resistant microorganisms. Hence, the current study was conducted to investigate the antibiotic sensitivity pattern of uropathogens in UTI.
Materials & Methods: A total of 642 urine samples were collected from suspected UTI patients and tested microbiologically. Antimicrobial susceptibility tests were performed for the isolated pathogens using the Kirby- Bauer disk diffusion method.
Results: Out of 642 urine samples, 308 (48%) were found to exhibit significant bacteriuria. Females had a higher rate of UTI (68%) than males (32%), with a higher prevalence in the middle-aged group, while males reported a higher prevalence in the elderly group, which was statistically significant. The most common organism was Escherichia coli (57.2%), followed by Klebsiella pneumoniae (26.3%), Pseudomonas aeruginosa (8.4%), Proteus spp. (3.6%), Enterococcus spp. (2.6%), and Staphylococcus aureus (1.9%). UTI were more common in middle-aged female patients (31 to 45 years), while in males, high prevalence was seen in older patients (>45 years). Meropenem, Gentamicin, Nitrofurantoin, and Co-Trimoxazole were amongst the most sensitive drugs against E.coli and K.pneumoniae.
Conclusion:Due to the irrational and injudicious use of antibiotics, commonly isolated uropathogens have a changing resistance pattern, resulting in reduced treatment effectiveness. This could be overcome by routine antimicrobial resistance surveillance, antimicrobial stewardship measures, and culture-guided therapy.

Keywords: Antibiotic susceptibility pattern, Antimicrobial resistance, Bacteriuria, Escherichia coli, Urinary tract infection, Uropathogens

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Type of Study: orginal article | Subject: Microbiology

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