Volume 7, Issue 2 (11-2021)                   RABMS 2021, 7(2): 100-103 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Matinkia M, Asghari R, Sharifi H. Low serum vitamin D levels in Iranians with immune thrombocytopenia: A single-center study. RABMS. 2021; 7 (2) :100-103
URL: http://ijrabms.umsu.ac.ir/article-1-96-en.html
Department of internal medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia-Iran. , mahsa.mtk92@gmail.com
Abstract:   (370 Views)
Background & Aims:  Immune thrombocytopenia is a disorder characterized by decreased platelet production and degradation. The objectives of our study were to assess the relationship between 1,25(OH)2D3 levels and ITP based on sex, age, and duration of disease.
Materials & Methods: The present study was retrospectively conducted by reviewing medical records of the ITP patients. Demographic data including age, sex, disease history and serum vitamin D levels were performed and collected in a pre-designed form. Data were reported as Mean ±SD and as frequency (percentage). Independent t-test or ANOVA tests were used to compare the mean serum levels of vitamin D in terms of sex, age or disease history.
Results: A total of 140 subjects (71 females and 69 males) with mean age± SD of 39.90 ± 16.11 years enrolled in the study. The mean serum vitamin D level in patients was 18.85 ± 10.87. There was no significant relationship between sex and serum vitamin D level (P=0.943). Patients in the range of 30-40 years have the most frequency and the lowest level of vitamin D in serum (17.11± 9.68 ng/ml). There was no association between age and vitamin D based on Pearson’s test (p=0.181). Vitamin D level in acute ITP patients was lower than chronic ITP patients, but this difference was not meaningful (p=0.403).
Conclusion: According to the findings of this study vitamin D can be administered as a new immunomodulatory therapy in patients with ITP.
Full-Text [PDF 269 kb]   (169 Downloads)    
Type of Study: orginal article | Subject: Special

References
1. Neunert C, Lim W, Crowther M. American Society of Hematology evidence-based practice guidelines for immune thrombocytopenia. Blood 2011. 117: 4190-207. [DOI:10.1182/blood-2010-08-302984] [PMID]
2. Bokow B, Kaplan T.Refractory immune thrombocytopenia successfully treated with high-dose vitamin D supplementation and hydroxychloroquine:two case reports, J Med Case Rep2013. 7:91. [DOI:10.1186/1752-1947-7-91] [PMID] [PMCID]
3. Thota S, Kistangari G, Daw H, Spiro T: Immune thrombocytopenia in adults: an update. Cleve Clin J Med 2012, 79(9):641-650. [DOI:10.3949/ccjm.79a.11027] [PMID]
4. Liu W, Li H, Hao Y, Li Y, Lv M, Xue F. Decreased immunosuppressive actions of 1, 25-dihydroxyvitaminD3in patients with immune thrombocytopenia. Mol Immunol 2016;78:89-97. [DOI:10.1016/j.molimm.2016.08.014] [PMID]
5. Lavi Arab F, Rastin M, Faraji F, Zamani Taghizadeh Rabe S, Tabasi N, Khazaee M. Assessment of1,25-dihydroxyvitamin D3 effects on Treg cells in a mouse model of systemiclupus erythematosus. Immunopharmacol Immunotoxicol 2015;37:12-8. [DOI:10.3109/08923973.2014.968255] [PMID]
6. Zerr P, Vollath S, Palumbo-Zerr K, Tomcik M, Huang J, Distler A. Vitamin D receptorregulates TGF-beta signalling in systemic sclerosis. Ann. Rheum. Dis 2015; 74: e20. [DOI:10.1136/annrheumdis-2013-204378] [PMID]
7. Schoonen WM, Kucera G, Coalson J. Epidemiology of immune thrombocytopenic purpura in the general practice research database. Br J Haematol 2009. 145: 235-44. [DOI:10.1111/j.1365-2141.2009.07615.x] [PMID]
8. Soliman A, Elsalakawy W, Saeed A. Low serum vitamin D levels in Egyptian adults with chronic primary Immune THROMBOCYTOPENIA: A SINGLE CENTER STUDY.. International J Adv Res 2017. 5(3):1789-97. [address]
9. Saeidi S, Jaseb K, Asnafi AA, Rahim F, Pourmotahari F, Mardaniyan S, et al. Immune Thrombocytopenic Purpura in Children and Adults: A Comparative Retrospective Study in IRAN. IJHOSCR 2014;8(3):30-6. [pubmed]
10. Cines DB and Bussel JB. How I treat thrombocytopenic purpura (ITP). Blood 2005; 106: 2244-51. [DOI:10.1182/blood-2004-12-4598] [PMID]
11. Neylon N, Saunders G, Howard R. Clinically significant newly diagnosed presenting autoimmune thrombocytopenic pupura in adults: a prospective study of a population-based cohort of 245 patients. Br J Haematol 2003; 122: 966-74. [DOI:10.1046/j.1365-2141.2003.04547.x] [PMID]
12. Emam FE, Abd El-Wahab TM, Mohammed MS, et al. Assessment of serum vitamin D level in patients with systemic lupus erythematosus. Egyptian Rheumatology and Rehabilitation 2014; 41: 71-8. [DOI:10.4103/1110-161X.132460]
13. Rossini M, Bongi MS, LaMontagna G, et al. Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability. Arthritis Res. Ther 2010; 12: R216. [DOI:10.1186/ar3195] [PMID] [PMCID]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Journal of Research in Applied and Basic Medical Sciences

Designed & Developed by : Yektaweb