دوره 8، شماره 3 - ( 4-1401 )                   جلد 8 شماره 3 صفحات 168-161 | برگشت به فهرست نسخه ها


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Fattahi bafghi A, Zare F, Gholamrezaei M, Ghafourzadeh M. The Role of Surface Molecules in Host Responses of Leishmaniasis: Focus on Lipid Mediators. RABMS 2022; 8 (3) :161-168
URL: http://ijrabms.umsu.ac.ir/article-1-195-fa.html
The Role of Surface Molecules in Host Responses of Leishmaniasis: Focus on Lipid Mediators. 1401; 8 (3) :168-161

URL: http://ijrabms.umsu.ac.ir/article-1-195-fa.html


چکیده:   (373 مشاهده)
Leishmaniasis is a neglected disease that affects more than 12 million people worldwide. After parasite inoculum by female blood-sucking insects, e.g. Phlebotomus, neutrophils quickly infiltrate and phagocytes Leishmania parasites. Macrophages are the second immune cells. They possess several pattern recognition receptors that respond to different surface molecules such as Lipophosphoglycan, glycoprotein 63 (GP63), PPG, GIPL, CP, and SAP. It was found that Leishmania GP63 cleaves several targets of infected macrophages, including the myristoylated alanine-rich C kinase substrate, p130CAS, PEST, NF-B, and AP-1. After activation of surface molecules, lipid metabolites of arachidonic acid, including leukotrienes and prostaglandins, are important mediators in Leishmaniasis. These lipid metabolites can be metabolized by different enzymes, including the cyclooxygenase and lipoxygenase.
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