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Abbasi M A, Rikhtegar E, Keshtkar Rajabi S. A Patient with Brucella with initial Manifestations similar to Crimean Congo Fever. Journal of Research in Applied and Basic Medical Sciences 2023; 9 (4) :229-232
URL: http://ijrabms.umsu.ac.ir/article-1-240-en.html
Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran , Rikhtegar.e@umsu.ac.ir
Abstract:   (176 Views)
The unusual manifestations of brucellosis as an endemic disease involving multiple organ systems include headache, confusion, acute abdomen, psoas abscess, endocarditis, perinephric mass, insulin resistance, and cauda-equina syndrome. In this paper we report a patient with such situations that was initially diagnosed and treated for Crimean-Congo hemorrhagic fever (CCHF) with partial improvement of symptoms after Ribavirin therapy and readmission for brucellosis and improvement of symptoms after combination therapy for the later diagnosis. A 31-year-old male patient was attended with intermittent fever and chill plus myalgia, melena, and hematuria since one week ago. He had also generalized abdominal pain and loss of appetite with a body mass index of 19 kg/m². He had a history of ten neonatal deaths of livestock in the last month. In laboratory tests, the liver enzymes were raised and pancytopenia was present. Patient received therapeutic dose of Ribavirin plus Apotel and the general status were improved. After one month, the patient was readmitted for fever plus right hip and knee pain, and the brucella IgG was in borderline level (10.36). He received treatment for brucellosis including Amikacin, Doxycycline, and Rifampin. The Wright and Coomb's Wright tests were positive. The general health was improved and the patient was discharged with administration of Doxycycline 100 mg twice a day and Rifampin 600 mg once a day. Totally, according to the reported case, it should be emphasized that Ribavirin is effective in the treatment of brucellosis.
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Type of Study: case report | Subject: Special

1. Kaya O, Avşar K, Zeynep Akçam F. Unusual manifestations of brucellosis. Arch Med Sci 2011;7(1):173-5. [DOI:10.5114/aoms.2011.20627] [PMID] []
2. Jayakumar RV, Al-Aska AK, Subesinghe N, Wright SG. Unusual presentation of culture positive brucellosis. Postgrad Med J 1988;64(748):118-20. [DOI:10.1136/pgmj.64.748.118] [PMID] []
3. Khorvash F, Keshteli AH, Behjati M, Salehi M, Emami Naeini A. An unusual presentation of brucellosis, involving multiple organ systems, with low agglutinating titers: a case report. J Med Case Rep 2007;1:53. [DOI:10.1186/1752-1947-1-53] [PMID] []
4. Loustaud-Ratti V, Debette-Gratien M, Jacques J, Alain S, Marquet P, Sautereau D, et al. Ribavirin: Past, present and future. World J Hepatol 2016;8(2):123-30. [DOI:10.4254/wjh.v8.i2.123] [PMID] []
5. Thomas E, Ghany MG, Liang TJ. The application and mechanism of action of ribavirin in therapy of hepatitis C. Antivir Chem Chemother 2012;23(1):1-12. [DOI:10.3851/IMP2125] [PMID] []
6. Duygu F, Sari T, Kaya T, Bulut N. Brucellosis in Patients with Crimean-Congo Hemorrhagic Fever. J Arthropod Borne Dis 2017;11(4):463-8. [] [PMID]
7. Shayan S, Bokaean M, Shahrivar MR, Chinikar S. Crimean-Congo Hemorrhagic Fever. Lab Med 2015;46(3):180-9. [DOI:10.1309/LMN1P2FRZ7BKZSCO] [PMID]
8. Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M. Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral Res 2013;100(1):159-89. [DOI:10.1016/j.antiviral.2013.07.006] [PMID]
9. Kara SS, Kara D, Fettah A. Various clinical conditions can mimic Crimean-Congo hemorrhagic fever in pediatric patients in endemic regions. J Infect Public Health 2016;9(5):626-32. [DOI:10.1016/j.jiph.2016.01.007] [PMID]
10. Kaya A, Engin A, Güven AS, İçağasıoğlu FD, Cevit Ö, Elaldı N, et al. Crimean-Congo hemorrhagic fever disease due to tick bite with very long incubation periods. Int J Infect Dis 2011;15(7):e449-52. [DOI:10.1016/j.ijid.2011.03.007] [PMID]
11. Ayatollahi J, Shahcheraghi SH, Mirjalili M. Report of nine cases of Crimean-Congo haemorrhagic fever From Iran. Niger Med J 2015;56(2):156-9. [DOI:10.4103/0300-1652.153409] [PMID] []
12. Flusin O, Iseni F, Rodrigues R, Paranhos-Baccalà G, Crance JM, Marianneau P, et al. Crimean-Congo hemorrhagic fever: basics for general practitioners. Med Trop (Mars). 2010; 70(5-6):429-38. [Google Scholar]
13. Metin O, Teke TA, Aydin ZG, Kaman A, Oz FN, Bayhan GI, et al. A case of brucellosis mimicking Crimean-Congo hemorrhagic fever. J Infect Public Health. 2015;8(3):302-4. [DOI:10.1016/j.jiph.2014.09.008] [PMID]
14. Karakeçili F, Çıkman A, Akın H, Gülhan B, Özçiçek A. A case of brucellosis and Crimean-Congo hemorrhagic fever coinfection in an endemic area. Mikrobiyol Bul 2016;50(2):322-7. [DOI:10.5578/mb.10821] [PMID]
15. Almiş H, Yakıncı C. A case of brucellosis misdiagnosed as Crimean-Congo hemorrhagic fever. Mikrobiyol Bul 2012;46(3):475-9. [Google Scholar]
16. Tanyel E, Sunbul M, Fletcher TE, Leblebicioglu H. Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area. Pathog Glob Health 2016;110(4-5):173-7. [DOI:10.1080/20477724.2016.1213958] [PMID] []
17. Bodur H, Akinci E, Ascioglu S, Öngürü P, Uyar Y. Subclinical infections with Crimean-Congo hemorrhagic fever virus, Turkey. Emerg Infect Dis 2012;18(4):640-2. [DOI:10.3201/eid1804.111374] [PMID] []

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