XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zeinalivand S, Parivar K, Hayati Roudbari N. Follicular growth and atresia and morphometric alteration of uterine tissue following letrozole administration in mature NMRI mice. Journal of Research in Applied and Basic Medical Sciences 2019; 5 (2) :103-110
URL: http://ijrabms.umsu.ac.ir/article-1-88-en.html
Department of Biology, Science and Research Campus, Azad University, Tehran, Iran , Selda.zv@gmail.com
Abstract:   (2334 Views)
Background & Aims:  Letrozole, as an aromatase inhibitor drug, is administrated to induce ovulation in individuals with anovulation disorder and, at the same time, it is used to enhance pregnancy success. The current study was designed to investigate the effect of Letrozole on follicular growth/atresia, as well as uterine histology. For this purpose, 15 mature female NMRI mice were assigned into 3 groups (NO=5 in each group): Control, Control sham, which received double distilled water, orally and experimental group received 0.5 mg/kg letrozole, orally.
Materials & Methods:  Following 14 days, the animals were euthanized and, the follicular number and percentage of atresia at different stages of growth and the morphometric changes of uterine tissue were analyzed and compared between groups.
Results:  The animals in experimental group represented no significant changes in primary, secondary, tertiary follicles, but exhibited a remarkable (p<0.05) reduction in graafian follicles number per two ovaries versus control and control-sham animals. Moreover, the letrozole -received mice exhibited diminished percentages of graafian follicles compared to control and control-sham animals. Finally, the endometrial thickness, as well as endometrial glands distribution per one mm2 of tissue were decreased in experimental group when compared to control and control-sham animals.
Conclusion: Letrozole significantly reduces the graafian  follicles atresia and via this mechanism up-regulates the ovulation ratio. However, it is able to prolong uterine development during a menstrual cycle.
Full-Text [PDF 1628 kb]   (1545 Downloads)    
Type of Study: orginal article | Subject: Special

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Research in Applied and Basic Medical Sciences

Designed & Developed by : Yektaweb